A fundamental question facing the cognitive sciences is why it is so difficult for us to look at the world in new ways. Experts, in particular, appear to have extreme difficulty in questioning the foundations for their belief. This I argue is because we can only view our world through mental paradigms. Such paradigms, our mindsets, have evolved so that we can respond automatically to things of importance but, by having mindsets, we are intrinsically prejudiced. I suggest that infantile autism (...) provides valuable insight into what a mind would be like if it were not to have paradigms. Because we are constrained to look at the world through our mindsets, the only way to see more is to acquire more mindsets. But, to actually be original, it is also necessary to subvert conventional wisdom and this would appear to be culturally dependent. Accordingly, understanding creativity necessitates examining the collective perspectives of diverse disciplines, encompassing abnormal minds as well as the historical transformations of different cultures. (shrink)

Steroid hormone receptors are ligand‐inducible transcription factors that exhibit potent effects on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell‐free systems. This article will describe the benefits of such systems and review their development up to the recent establishment of steroid receptor‐dependent in vitro transcription. Subsequent advances in our knowledge of receptor function arising from the exploitation of this powerful experimental tool will be described. (...) Particular emphasis will be placed upon two key problems: the role of steroid hormone in receptor action and the mechanisms by which steroid receptors activate gene transcription. (shrink)

Background: Current practice frequently fails to provide care consistent with the preferences of decisionally-incapacitated patients. It also imposes significant emotional burden on their surrogates. Algorithmic-based patient preference predictors (PPPs) have been proposed as a possible way to address these two concerns. While previous research found that patients strongly support the use of PPPs, the views of surrogates are unknown. The present study thus assessed the views of experienced surrogates regarding the possible use of PPPs as a means to help make (...) treatment decisions for decisionally-incapacitated patients. -/- Methods: This qualitative study used semi-structured interviews to determine the views of experienced surrogates [n=26] who were identified from two academic medical centers and two community hospitals. The primary outcomes were respondents’ overall level of support for the idea of using PPPs and the themes related to their views on how a PPP should be used, if at all, in practice. -/- Results: Overall, 21 participants supported the idea of using PPPs. The remaining five indicated that they would not use a PPP because they made decisions based on the patient’s best interests, not based on substituted judgment. Major themes which emerged were that surrogates, not the patient’s preferences, should determine how treatment decisions are made, and concern that PPPs might be used to deny expensive care or be biased against minority groups. -/- Conclusions: Surrogates, like patients, strongly support the idea of using PPPs to help make treatment decisions for decisionally-incapacitated patients. These findings provide support for developing a PPP and assessing it in practice. At the same time, patients and surrogates disagree over whose preferences should determine how treatment decisions are made, including whether to use a PPP. These findings reveal a fundamental disagreement regarding the guiding principles for surrogate decision-making. Future research is needed to assess this disagreement and consider ways to address it. (shrink)

How do attempts to foresee the future actually change it? For thousands of years, humans have called upon foresight to shape their own actions in order to adapt and survive; as Charles Darwin revealed in his theory of natural selection, the capacity to do just that is key to the origin of species. The uses of foresight, however, can also be applied to help us further our understanding across a variety of realms in everything from warfare, journalism and music, to (...) ancient civilizations, space weather and science. In a thought-provoking new addition to the Darwin College Lecture Series, eight distinguished authors each present an essay from their area of expertise devoted to the theme of 'foresight'. This provocative read reveals foresight as a process that can be identified across all areas of human endeavour, an art which can not only predict the future, but make it anything but inevitable. (shrink)

As automobile manufacturers have begun to design, engineer, and test autonomous driving systems of the future, brain imaging with functional near-infrared spectroscopy can provide unique insights about cognitive processes associated with evolving levels of autonomy implemented in the automobile. Modern fNIRS devices provide a portable, relatively affordable, and robust form of functional neuroimaging that allows researchers to investigate brain function in real-world environments. The trend toward “naturalistic neuroscience” is evident in the growing number of studies that leverage the methodological flexibility (...) of fNIRS, and in doing so, significantly expand the scope of cognitive function that is accessible to observation via functional brain imaging. While more than a decade’s worth of study in this field of fNIRS driving research has led to many interesting findings, the number of studies applying fNIRS during autonomous modes of operation is limited. To support future research that directly addresses this lack in autonomous driving research with fNIRS, we argue that a cogent distillation of the methods used to date will help facilitate and streamline this research of tomorrow. To that end, here we provide a methodological review of the existing fNIRS driving research, with the overarching goal of highlighting the current diversity in methodological approaches. We argue that standardization of these approaches will facilitate greater overlap of methods by researchers from all disciplines, which will, in-turn, allow for meta-analysis of future results. We conclude by providing recommendations for advancing the use of such fNIRS technology in furthering understanding the adoption of safe autonomous vehicle technology. (shrink)

Balancing Change and Tradition in Global Education Reform is an invaluable resource for policymakers, faculty, students, and anyone interested in how decisions made about the education system ultimately affect the quality of education, educational access, and social justice.

It is not unusual to speculate on the contrary-to-fact implications of political assassinations. Lincoln's is the classic case in point, but we need only think of Julius Caesar, Gandhi, or John Kennedy, if we require further examples. One totally neglected case in this context is that of Moritz Schlick. One of the remote consequences of his murder, on June 22, 1936, which was most definitely a political assassination, is that today's academic world may well have been an entirely different one (...) if he had gone on to lead the Vienna Circle into exile. That group of young philosophers of science had formed as he assumed the University of Vienna's chair of natural philosophy in 1922. A quarter of a century later, the entire English-speaking world (and Scandinavia) was in thrall to “logical positivism,” a caricature of scientific philosophy as the circle conceived it but an incredibly powerful intellectual standpoint, for all that. The view that all genuine knowledge can be quantified not only dominated philosophy but transformed the nature of universities to the point of threatening the very existence of the humanities, which could scarcely meet this demand. The polemical and oversimplified view of Rudolf Carnap's strong program for scientific philosophy simply found no place for disciplines based on mere description (ethnology) or on understanding complex interlinked constellations of events as they develop over time (history and its myriad allied disciplines).The die was cast, and the humanities became saddled with an inferiority complex that, even today, they have only partially shaken off. Only disciplines that employed mathematical methods in aid of rigorous explanation, working collectively in networks like those of physics or chemistry, were worthy of being institutionalized at universities. Since the humanities were, for the most part, embodied in individual researchers burning the Midnight Oil as they pondered the Eternal Verities, they were disqualified as sciences. They would have to reform themselves radically or disappear. The battle commenced, and sensitive observers can attest that, administrative rhetoric to the contrary, it still goes on. Had Schlick lived on, the pluralism and tolerance that was part of his view of the world might well have carried more influence than the more radical elements in the group ultimately did, and so the humanities might well have fared better in a more secure environment than they have done.Edmonds's The Murder of Professor Schlick does not venture into such speculations. Instead, it offers us a vibrant, suspense-filled narrative replete with as much information as the reader can digest (and more). Briefly, Edmonds presents a fully detailed, complex version of the high drama of the rise and decline of logical positivism in both its philosophical and its political dimensions, complete with vivid portraits of the characters whose thought and personalities supplied that movement with its dazzling dynamism. They include such characters as Schlick himself; the irrepressible Otto Neurath, who had been a minister in the short-lived Bavarian Soviet Republic; Rudolf Carnap, the circle's standard-bearer; Ludwig Wittgenstein, its unwilling ideal; Bertrand Russell, its Promethean inspiration; the eccentric Kurt Gödel; the rabbi Josef Schächter; the clever Englishman A. J. Ayer; America's rising star, W. V. Quine; the perennial contrarian, Karl Popper; the unfortunate Friedrich Waismann, doomed to failure in all his efforts; the tragic Edgar Zilsel, who committed suicide in American exile; and several frequently neglected women, such as Rose Rand, Olga Hahn, Marie Reidemeister, and Olga Taussky. In addition, the strong Jewish presence in the circle and the surrounding anti-Semitism that was a continuing stumbling block to it are clearly and powerfully described.These are but highlights of Edmond's narrative, but they are proof positive that his study is where to begin an encounter with the Vienna Circle and thus with the philosophical view that, more than any other, has conferred its character on modern thought and deeply molded people who have never heard of it. (shrink)